Faculty Research Interests

Robert H. Allen, M.D.

Nerve regeneration after trauma.

Christopher O. Bayne, M.D.

Biomechanics, imaging, and surgical treatment of carpal instability; microvascular skeletal reconstruction for the treatment of traumatic bony defects a nonunion.

Blaine A. Christiansen, Ph.D.

Mechanisms of post-traumatic osteoarthritis, bone adaptation to mechanical stimuli, systemic bone response to bone fracture, effect of age in bone mechano-adaptation, advanced imaging of musculoskeletal structure and metabolism.

Jonathan G. Eastman, M.D.

Implant biomechanics and compression techniques with specific interest in pelvic injury and stabilization models.

Ellen P. Fitzpatrick, M.D.

Functional and clinical outcomes following orthopaedic trauma surgery, lower extremity peri-articular trauma, implant biomechanics.

David P. Fyhrie, Ph.D.

Bone and cartilage mechanical properties and risk of osteoporotic fractures; mechanical failure of collagenous structures and rejection of water: implications for bone fracture.

Mauro M. Giordani, M.D.

Total joint arthroplasty, knee and hip abductor tendinopathy/tears.

Eric Giza, M.D.

Clinical application of juvenile articular cartilage allografts for osteochondral defects in the talus; arthroscopic approaches to lateral ligament stabilization; bioscaffold treatments for articular cartilage defects; arthroscopic approaches to syndesmosis stabilization; radiographic changes in foot x-rays with progressive weight-bearing; biomechanical testing of Lisfranc injury fixation methods.

Dominik R. Haudenschild, Ph.D.

We study early responses to joint injury to learn about the pathogenesis of osteoarthritis and to identify intervention strategies.  We study chondrocyte mechanobiology to understand how mechanical forces are translated into biochemical responses.  We study cartilage matricellular proteins to gain insight into how cells interact with growth factors and the extracellular matrix.
 
We use animal models of joint injury and bone formation, explant models of osteochondral injuries, stem-cell based tissue engineering, and 3-axis bioreactors to mechanically stimulate hydrogel-embedded chondrocytes and stem cells.
 
We apply the knowledge to translational studies. Example: Intervene with inflammatory gene expression upon joint injury to prevent or delay OA. Example: Enhance BMP-mediated bone regeneration by presenting the growth factor in a biologically relevant context on matricellular proteins.

Brian M. Haus, M.D. 

Non-surgical and surgical outcomes of pediatric sports injuries.

Michelle A. James, M.D.

Analysis of upper extremity function in children; funded studies of prosthesis use in children with below elbow deficiency and treatment of upper extremity cerebral palsy; motion analysis of the upper extremity in children and teenagers with brachial plexus birth palsy and spinal cord injury; motion analysis of thumb abduction and opposition; outcomes of nerve reconstruction for infants with brachial plexus birth palsy; outcomes of pinch reconstruction in people with tetraplegia; stereognosis assessment in children with upper extremity cerebral palsy; molecular biology of limb deficiency.

Eric O. Klineberg, M.D.

I am very invested in clinical outcomes research, particularly in the setting of spinal deformity.  Much of this work is focused on spinopelvic parameters, sagittal balance and the influence of deformity correction on patient outcomes.  Much of this work is now referenced, and is a guideline for deformity correction around the globe.  More information on the International Spine Study Group (ISSG) may be found online at SpineDeformityBlog.com.
 
My basic science research focus is on stem cells for bone regeneration, the biology of spine fusion, and characterization of disc degeneration. Ultimately the goal is to derive biological and biomechanical solutions to provide an optimal fusion or regeneration platform that will consist of matrix, cells and proteins. Many different collaborators are involved in this research endeavor. 

Christopher D. Kreulen, M.D.

Surgical treatment of osteochondral defects of the talus; use of bone marrow aspirate in orthopaedic surgery; advancing the techniques in Achilles surgery and rehabilitation.

J. Kent Leach, Ph.D.

Identification of signals for optimal bone formation; enhancement of bone differentiation by cell-secreted extracellular matrix; secretion of proangiogenic factors in vivo angiogenesis; cell instructive materials to direct stem cell fate for bone formation and regeneration; soluble and insoluble stimuli to promote bone formation; bioreactor design and usage to generate osteogenic grafts.

Cassandra A. Lee, M.D.

Tissue engineering for articular cartilage defects; integration of self-assembled cartilage constructs for trochlear defects in rabbits.

Mark A. Lee, M.D.

Adipose-derived and bone marrow derived mesenchymal stem cells in treatment of atrophic nonunions in rats; BMPs and biomechanics of fracture healing.

Joel A. Lerman, M.D.

Function and clinical outcomes in patients with congenital lower extremity deficiencies, as well as orthopaedic issues in spinal cord injured youths, spinal deformities and clubfeet.

Richard A. Marder, M.D.

Prospective, randomized study of rotator cuff syndrome using subacromial bursa; biomechanics of medial patellofemoral ligament repair in reconstruction.

Gavin C.T. Pereira, M.B.B.S. 

3D printed bone models for preoperative surgical planning and resident training; computer navigation and knee kinematics; short femoral stems in hip replacements; infections in joint replacements.

A. Hari Reddi, Ph.D.

Stem cells for chondrogenesis: isolation from bone marrow, muscle and synovium; tissue engineering and regeneration of articular cartilage; engineering lubrication in tissue engineered cartilage.

Rolando F. Roberto, M.D.

Infections in spinal surgery; adult sagittal plane deformity correction with osteotomy pedicle subtraction; opiate sparing multimodal pain management protocols in pediatric and adult spinal surgery; implementation of a universal protocol to reduce surgical site infection in pediatric patients; cost and complications associated with the use of autologous iliac crest bone graft compared to rhBMP-2.

Robert M. Szabo, M.D.

Dynamic MRI imaging during wrist and forearm motion to assess carpal kinematics; hypermobility of the trapeziometacarpal joint of the thumb in hand osteoarthritis; improvement of clinical care of patients with carpal tunnel syndrome.

Steven W. Thorpe, M.D.

Outcomes and innovations in limb sparing surgery for treatment of bone and soft tissue sarcoma;  outcomes and innovations in pelvic resections and reconstruction for sarcoma of the pelvis; determination of the role of cancer stem cells in the propagation and development of metastases and relapse in bone and soft tissue sarcoma.

James Van den Bogaerde, M.D.

Anatomic, biomechanical and clinical outcome studies in knee, shoulder and elbow surgery.

Philip R. Wolinsky, M.D.

Healing and non-healing acute fractures: are these differences in mesenchymal stem cells; clinical investigations to predict non-unions in traumatic fractures.